Periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI)

A Boillot; H Range; N Danchin; S Kotti; G Cosler; S Czernichow; O Meilhac; E Puymirat; M Zeller; D Tchetche; P Bouchard; T Simon

doi:10.1136/jech-2015-207043

Periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI)

J Epidemiol Community Health. 2016 Dec;70(12):1236-1241. doi: 10.1136/jech-2015-207043. Epub 2016 Jun 20.

Authors

A Boillot^{1

2}, H Range^{1

3}, N Danchin^{4

5}, S Kotti⁶, G Cosler³, S Czernichow^{2

7}, O Meilhac^{8

9}, E Puymirat^{4

5}, M Zeller¹⁰, D Tchetche¹¹, P Bouchard^{1

12}, T Simon^{3

6

13}

Affiliations

¹ Department of Periodontology, Rothschild Hospital (AP-HP); UFR of Odontology, University of Paris Diderot, Paris, France.
² INSERM UMRS 011, Population-based Cohort Platform, Villejuif, France.
³ INSERM UMRS 1148, Laboratory for Vascular Translational Science, Paris, France.
⁴ Department of Cardiology, AP-HP, Georges Pompidou European Hospital, Paris, France.
⁵ University of Paris-Descartes, Paris, France.
⁶ Assistance Publique-Hôpitaux de Paris (APHP), St Antoine Hospital, URC-EST, Paris, France.
⁷ Department of Nutrition, Ambroise Paré Hospital (AP-HP), University of Versailles Saint Quentin en Yvelines, Boulogne-Billancourt, France.
⁸ INSERM UMRS 1188, Diabète athérothrombose Thérapies Réunion Océan Indien, Sainte Clotilde, La Réunion, France.
⁹ La Réunion University, Sainte Clotilde, La Réunion, France.
¹⁰ Department of Cardiology, Dijon University Hospital, Dijon, France.
¹¹ Department of Cardiology, Clinique Pasteur, Toulouse, France.
¹² EA 2496, UFR of Odontology, University of Paris Descartes, Montrouge, France.
¹³ Department of Clinical Pharmacology, University of Pierre et Marie Curie, Paris, France.

PMID: 27325868
DOI: 10.1136/jech-2015-207043

Abstract

Background: Periodontopathogens antibodies have been shown to be associated with primary myocardial events, but little is known regarding their impact on major adverse events after a prior acute myocardial infarction (AMI). The present prospective study evaluates the association between antibody levels of 4 periodontopathogens and the risk of all-cause death or non-fatal myocardial infarction (MI) at 1 year in 975 patients admitted for acute ST segment or non-ST segment elevation MI in French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI), a nationwide French survey.

Methods: Multiserotype ELISAs were performed to assess levels of IgG and IgA against Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Tannerella forsythia.

Results: Adjusted HRs indicate the lack of association between IgG-anti-Po. gingivalis levels (0.96 (0.78 to 1.18)), IgA-anti-Po. gingivalis levels (1.13 (0.90 to 1.42)) and the risk of all-cause death or non-fatal MI at 1 year. Additionally, no significant association was found between the occurence of an event at 1 year and immunoglobulins levels against the others periodontopathogens.

Conclusions: The present data indicate that circulating levels of periodontopathogens antibodies are not associated with an increased risk of major adverse events in patients with a prior AMI. Studies dealing with bacterial and clinical data are needed to assess the role of oral health in comprehensive cardiac rehabilitation programmes.

Keywords: Cardiovascular disease; Cohort studies; DENTAL HEALTH; Epidemiology of cardiovascular disease.

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