Modification of PDMS to fabricate PLGA microparticles by a double emulsion method in a single microfluidic device

Leila Montazeri; Shahin Bonakdar; Mojtaba Taghipour; Philippe Renaud; Hossein Baharvand

doi:10.1039/c6lc00437g

Modification of PDMS to fabricate PLGA microparticles by a double emulsion method in a single microfluidic device

Lab Chip. 2016 Jul 5;16(14):2596-600. doi: 10.1039/c6lc00437g.

Authors

Leila Montazeri¹, Shahin Bonakdar², Mojtaba Taghipour³, Philippe Renaud³, Hossein Baharvand⁴

Affiliations

¹ Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Baharvand@Royaninstitute.org and Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
² National Cell Bank, Pasteur Institute of Iran, Tehran, Iran.
³ Microsystems Laboratory, École Polytechnique Fédérale de Lausanne, EPFL-STI-IMT-LMIS4, Station 17, Lausanne, 1015, Switzerland. Philippe.renaud@epfl.ch.
⁴ Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Baharvand@Royaninstitute.org and Department of Developmental Biology, University of Science and Culture, ACECR, Tehran, Iran.

PMID: 27334791
DOI: 10.1039/c6lc00437g

Abstract

We present an easy, durable method to generate a partially hydrophilic/hydrophobic poly(dimethylsiloxane) (PDMS) microfluidic device. The functionality of this device was assessed in a double flow focusing design to fabricate core-shell structured poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs).

Publication types

Research Support, Non-U.S. Gov't