Thrombocytopenia-associated multiorgan failure occurring in an infant at the onset of type 1 diabetes successfully treated with fresh frozen plasma

Revati Kumar; Brent McSharry; Peter Bradbeer; Esko Wiltshire; Craig Jefferies

doi:10.1002/ccr3.587

Thrombocytopenia-associated multiorgan failure occurring in an infant at the onset of type 1 diabetes successfully treated with fresh frozen plasma

Clin Case Rep. 2016 Jun 2;4(7):671-4. doi: 10.1002/ccr3.587. eCollection 2016 Jul.

Authors

Revati Kumar¹, Brent McSharry², Peter Bradbeer³, Esko Wiltshire⁴, Craig Jefferies⁵

Affiliations

¹ University College London London WC1E 6BT UK.
² Department of Pediatric Intensive care Starship Children's Hospital Auckland New Zealand.
³ Starship Blood and Cancer Centre Starship Children's Hospital Auckland New Zealand.
⁴ Departments of Paediatrics and Child Health University of Otago Wellington Wellington New Zealand.
⁵ Department of Pediatric Diabetes and Endocrinology Starship Children's Hospital Auckland New Zealand.

Abstract

TAMOF is a devastating microangiopathy that can occur in association with the new onset of T1DM, and should be considered with the onset of thrombocytopenia, renal failure, and raised LDH. Treatment with fresh frozen plasma should be considered as a first-line option in such cases prior to plasma exchange.

Keywords: Acute kidney injury; diabetes; diabetic ketoacidosis; thrombotic thrombocytopenia.

Publication types

Case Reports