Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease

Haematologica. 2016 Oct;101(10):e397-e400. doi: 10.3324/haematol.2016.148106. Epub 2016 Jul 14.
No abstract available

Keywords: calpain-1; genetic inactivation; humanized mouse model; pain; sickle cell disease.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Sickle Cell / genetics*
  • Anemia, Sickle Cell / metabolism
  • Anemia, Sickle Cell / pathology
  • Animals
  • Calpain / deficiency
  • Calpain / genetics*
  • Disease Models, Animal*
  • Gene Deletion
  • Gene Silencing / physiology*
  • Humans
  • Mice
  • Mice, Knockout
  • Pain / genetics*
  • Pain / metabolism
  • Pain / prevention & control*

Substances

  • Calpain
  • Capn1 protein, mouse