Linking cancer-induced Nlrp3 inflammasome activation to efficient NK cell-mediated immunosurveillance

Maryse Dagenais; Maya Saleh

doi:10.1080/2162402X.2015.1129484

Linking cancer-induced Nlrp3 inflammasome activation to efficient NK cell-mediated immunosurveillance

Oncoimmunology. 2016 Apr 22;5(5):e1129484. doi: 10.1080/2162402X.2015.1129484. eCollection 2016 May.

Authors

Maryse Dagenais¹, Maya Saleh²

Affiliations

¹ Department of Biochemistry, McGill University , Montreal, Quebec, Canada.
² Department of Biochemistry, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Microbiology and Immunology McGill University, Montreal, Quebec, Canada.

Abstract

We have recently demonstrated that the Nlrp3 inflammasome can detect the presence of colorectal cancer (CRC) metastatic growth in the liver and limit its growth. Inflammasome signaling primed natural killer (NK) cells through Interleukin (IL)-18 and activated their ability to trigger FasL-induced apoptosis of the tumor.

Keywords: Apoptosis; Fas; NK cells; Nlrp3 inflammasome; cancer; immunosurveillance; immunotherapy; innate immunity.