BH3 profiling as a tool to identify acquired resistance to venetoclax in multiple myeloma

Br J Haematol. 2017 Nov;179(4):684-688. doi: 10.1111/bjh.14251. Epub 2016 Jul 29.
No abstract available

Keywords: BCL2 family members; Venetoclax; apoptosis; resistance.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Biomarkers, Tumor*
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
  • Bridged Bicyclo Compounds, Heterocyclic / therapeutic use
  • Drug Resistance, Neoplasm / genetics*
  • Gene Expression Profiling*
  • Humans
  • Melanoma / diagnosis
  • Melanoma / drug therapy
  • Melanoma / genetics*
  • Molecular Mimicry*
  • Protein Interaction Domains and Motifs*
  • Sulfonamides / pharmacology*
  • Sulfonamides / therapeutic use

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Bridged Bicyclo Compounds, Heterocyclic
  • Sulfonamides
  • venetoclax