NAGging Hexokinase PEPs up NLRP3

Henry Hampton; Carolyn Hutcheon; Naeha Subramanian

doi:10.1016/j.chom.2016.07.017

NAGging Hexokinase PEPs up NLRP3

Cell Host Microbe. 2016 Aug 10;20(2):130-2. doi: 10.1016/j.chom.2016.07.017.

Authors

Henry Hampton¹, Carolyn Hutcheon¹, Naeha Subramanian²

Affiliations

¹ Institute for Systems Biology, Seattle WA 98109, USA.
² Institute for Systems Biology, Seattle WA 98109, USA; Departments of Immunology and Global Health, University of Washington, Seattle, WA 98195, USA. Electronic address: nsubrama@systemsbiology.org.

PMID: 27512900
DOI: 10.1016/j.chom.2016.07.017

Abstract

Recognition of peptidoglycan is integral to detection of gram-positive bacterial pathogens. In a recent issue of Cell, Wolf et al. (2016) report that detection of the N-acetylglucosamine component of peptidoglycan by the glycolytic enzyme hexokinase activates the NLRP3 inflammasome, revealing an intriguing interplay between pathogen detection and metabolism.

Publication types

Comment

MeSH terms

Acetylglucosamine
Cell Wall
Hexokinase*
Inflammasomes
Peptidoglycan*

Substances

Inflammasomes
Peptidoglycan
Hexokinase
Acetylglucosamine