ZNF217/ZFP217 Meets Chromatin and RNA

Dung-Fang Lee; Martin J Walsh; Francesca Aguiló

doi:10.1016/j.tibs.2016.07.013

ZNF217/ZFP217 Meets Chromatin and RNA

Trends Biochem Sci. 2016 Dec;41(12):986-988. doi: 10.1016/j.tibs.2016.07.013. Epub 2016 Aug 9.

Authors

Dung-Fang Lee¹, Martin J Walsh², Francesca Aguiló³

Affiliations

¹ Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
² Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: martin.walsh@mssm.edu.
³ Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Current address: Wallenberg Centre for Molecular Medicine, Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden. Electronic address: francesca.aguilo@mssm.edu.

Abstract

The Kruppel-like transcription factor zinc finger protein (ZNF)217 (mouse homolog ZFP217) contributes to tumorigenesis by dysregulating gene expression programs. The newly discovered molecular function of ZFP217 in controlling N6-methyladenosine (m⁶A) deposition in embryonic stem cells (ESCs) sheds new light on the role of this transcription factor in tumor development.

Keywords: N6-methyladenosine; RNA methylation; ZNF217; cancer; stem cell.

MeSH terms

Adenosine / analogs & derivatives*
Adenosine / metabolism
Animals
Cadherins / genetics
Cadherins / metabolism
Carcinogenesis / genetics*
Carcinogenesis / metabolism
Carcinogenesis / pathology
Chromatin / chemistry
Chromatin / metabolism
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Enhancer of Zeste Homolog 2 Protein / genetics
Enhancer of Zeste Homolog 2 Protein / metabolism
Gene Expression Regulation, Neoplastic*
Histone Deacetylases / genetics
Histone Deacetylases / metabolism
Histone-Lysine N-Methyltransferase / genetics
Histone-Lysine N-Methyltransferase / metabolism
Humans
Jumonji Domain-Containing Histone Demethylases / genetics
Jumonji Domain-Containing Histone Demethylases / metabolism
Methylation
Mice
Mouse Embryonic Stem Cells / metabolism
Mouse Embryonic Stem Cells / pathology
RNA Processing, Post-Transcriptional*
RNA, Messenger / genetics
RNA, Messenger / metabolism*
Trans-Activators / genetics
Trans-Activators / metabolism*
Transcription, Genetic

Substances

Cadherins
Cdh1 protein, mouse
Chromatin
DNA-Binding Proteins
RNA, Messenger
Trans-Activators
ZFP217 protein, mouse
ZNF217 protein, human
N-methyladenosine
Jumonji Domain-Containing Histone Demethylases
Kdm5b protein, mouse
Enhancer of Zeste Homolog 2 Protein
Ezh2 protein, mouse
G9a protein, mouse
Histone-Lysine N-Methyltransferase
Histone Deacetylases
Adenosine

Abstract

MeSH terms

Substances

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