Effects of peptides from Phascolosoma esculenta on spatial learning and memory via anti-oxidative character in mice

Neurosci Lett. 2016 Sep 19:631:30-35. doi: 10.1016/j.neulet.2016.08.012. Epub 2016 Aug 9.

Abstract

This study was aimed to evaluate effects of peptides from Phascolosoma esculenta and its ferrous-chelating peptides on spatial learning and memory in mice by Morris water maze test. 100mg/kg peptide on spatial learning and memory function about quadrant time and passing times through the platform better than 50 and 150mg/kg group during exploration period (P<0.05), without body weight between the weight and visual ability. 100mg/kg ferrous-chelating peptide group performed better ability of spatial learning and memory than 100mg/kg peptide group (P<0.05). qRT-PCR results showed that 50 and 100mg/kg administration peptide and 100mg/kg ferrous-chelating peptide can significantly improve mRNA expression of NR2A, NR2B and BDNF with oxidative stress status (GSH-Px, SOD, TAC and MDA), which explained mechanism for improving learning and memory ability in mice via anti-oxidative character.

Keywords: Ferrous-chelating peptide; Learning and memory; Morris water maze; Peptide; Phascolosoma esculenta.

MeSH terms

  • Animals
  • Antioxidants / administration & dosage*
  • Body Weight / drug effects
  • Brain-Derived Neurotrophic Factor / metabolism
  • Cyclic AMP Response Element-Binding Protein / metabolism
  • Exploratory Behavior / drug effects
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Iron Chelating Agents / administration & dosage*
  • Maze Learning / drug effects
  • Mice
  • Mice, Inbred ICR
  • Oxidative Stress
  • Peptides / administration & dosage*
  • Peptides / isolation & purification
  • Polychaeta* / chemistry
  • RNA, Messenger / metabolism
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Spatial Learning / drug effects*
  • Spatial Memory / drug effects*
  • Swimming

Substances

  • Antioxidants
  • Brain-Derived Neurotrophic Factor
  • Creb1 protein, mouse
  • Cyclic AMP Response Element-Binding Protein
  • Iron Chelating Agents
  • NR2A NMDA receptor
  • NR2B NMDA receptor
  • Peptides
  • RNA, Messenger
  • Receptors, N-Methyl-D-Aspartate