Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

Affiliations

• ¹ Duke Clinical Research Institute, Duke Medicine, Durham, NC. Electronic address: thomas.povsic@duke.edu.
• ² University of Virginia, Charlottesville, Va.
• ³ Cleveland Clinic Coordinating Center for Clinical Research (C5Research), Cleveland, Ohio.
• ⁴ Mount Sinai School of Medicine, New York, NY.
• ⁵ Regado Biosciences, Basking Ridge, NJ.
• ⁶ Duke Clinical Research Institute, Duke Medicine, Durham, NC.
• ⁷ Sailstad and Associates, Inc, Durham, NC.
• ⁸ Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada.
• ⁹ Université Paris-Diderot, Sorbonne Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris, Paris, France; NHLI, Royal Brompton Hospital, Imperial College, London, United Kingdom.
• ¹⁰ University of Freiburg, Freiburg, Germany.
• ¹¹ University of Cincinnati College of Medicine, Cincinnati, Ohio.
• ¹² Johns Hopkins Asthma and Allergy Center, Baltimore, Md.
• ¹³ Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.