Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014-2015

Emerg Infect Dis. 2016 Sep;22(9):1640-3. doi: 10.3201/eid2209.152058.

Abstract

We observed multidrug resistance in 10 (91%) of 11 Shigella isolates from a diarrheal surveillance study in Cambodia. One isolate was resistant to fluoroquinolones and cephalosporins and showed decreased susceptibility to azithromycin. We found mutations in gyrA, parC, β-lactamase, and mphA genes. Multidrug resistance increases concern about shigellosis treatment options.

Keywords: Cambodia; MDR genes; Shigella; antimicrobial resistance; bacteria; bacterial infections; dysentery; enteric infections.

Publication types

  • Historical Article

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Cambodia / epidemiology
  • Child, Preschool
  • Diarrhea / drug therapy
  • Diarrhea / epidemiology*
  • Diarrhea / history
  • Diarrhea / microbiology*
  • Drug Resistance, Multiple, Bacterial*
  • Dysentery, Bacillary / drug therapy
  • Dysentery, Bacillary / epidemiology*
  • Dysentery, Bacillary / history
  • Dysentery, Bacillary / microbiology*
  • Female
  • Genes, Bacterial
  • History, 21st Century
  • Humans
  • Infant
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mutation
  • Population Surveillance
  • Shigella / drug effects*
  • Shigella / genetics
  • Young Adult

Substances

  • Anti-Bacterial Agents