BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea-Induced Gliomagenesis

Am J Pathol. 2016 Oct;186(10):2551-4. doi: 10.1016/j.ajpath.2016.07.005. Epub 2016 Aug 18.

¹ Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
² Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
³ Pathobiology and Translational Science Graduate Program, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Department of Neurology and Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina. Electronic address: rmiller@med.unc.edu.

Abstract

This commentary highlights the article by Wang et al that describes a preclinical model for targeting BRAF-mutant gliomas.