Primary angiomatoid fibrous histiocytoma of the lung with mediastinal lymph node metastasis

Hum Pathol. 2016 Dec:58:134-137. doi: 10.1016/j.humpath.2016.07.022. Epub 2016 Aug 18.

Abstract

Angiomatoid fibrous histiocytoma (AFH), a rare soft tissue tumor of borderline malignancy, typically occurs in the subcutis of the accessible soft tissues, most often in children and young adults. Lymph node and/or distant metastasis is seen in less than 2% of patients with AFH. Exceptionally rare examples of AFH have been reported in visceral locations, including the lung. We report a genetically confirmed primary pulmonary AFH in a 70-year-old woman with mediastinal lymph node metastasis, representing to the best of our knowledge the first report of metastases from a visceral AFH.

Keywords: Angiomatoid fibrous histiocytoma; EWSR1; Fluorescence in situ hybridization; Pulmonary neoplasms; Soft tissue neoplasms.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / genetics
  • Biopsy
  • Calmodulin-Binding Proteins / genetics
  • Female
  • Gene Rearrangement
  • Histiocytoma, Malignant Fibrous / chemistry
  • Histiocytoma, Malignant Fibrous / genetics
  • Histiocytoma, Malignant Fibrous / secondary*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Lung Neoplasms / chemistry
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology*
  • Lymph Nodes / chemistry
  • Lymph Nodes / pathology*
  • Lymphatic Metastasis
  • Mediastinum
  • RNA-Binding Protein EWS
  • RNA-Binding Proteins / genetics
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor
  • Calmodulin-Binding Proteins
  • EWSR1 protein, human
  • RNA-Binding Protein EWS
  • RNA-Binding Proteins

Supplementary concepts

  • Histiocytoma, Angiomatoid Fibrous