Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains

Mahdi Abastabar; Nooshin Rahimi; Jacques F Meis; Narges Aslani; Sadegh Khodavaisy; Mojtaba Nabili; Ali Rezaei-Matehkolaei; Koichi Makimura; Hamid Badali

doi:10.1128/AAC.01193-16

Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6916-6919. doi: 10.1128/AAC.01193-16. Print 2016 Nov.

Authors

Affiliations

¹ Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
² Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
³ Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
⁴ Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
⁵ Department of Medical Mycology and Parasitology, Tehran University of Medical Science, Tehran, Iran.
⁶ Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁷ Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Japan/Asia International Institute of Infectious Diseases Control, Teikyo University, and Teikyo University Institute of Medical Mycology, Tokyo, Japan.
⁸ Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran badalii@yahoo.com.
⁹ Department of Medical Mycology and Parasitology, Mazandaran University of Medical Sciences, Sari, Iran.

Abstract

A collection of azole-susceptible (n = 141) and azole-resistant (n = 27) Aspergillus fumigatus isolates was tested against seven antifungal drugs, including the new imidazoles lanoconazole and luliconazole. The luliconazole and lanoconazole MIC₉₀ values for the azole-susceptible strains were 0.001 μg/ml and 0.008 μg/ml, and those for the azole-resistant strains were 0.016 μg/ml and 0.032 μg/ml.

MeSH terms

Antifungal Agents / pharmacology*
Aspergillus fumigatus / drug effects*
Aspergillus fumigatus / genetics
Aspergillus fumigatus / isolation & purification
Azoles / pharmacology
Drug Resistance, Fungal / drug effects*
Humans
Imidazoles / pharmacology*
Microbial Sensitivity Tests

Substances

Antifungal Agents
Azoles
Imidazoles
latoconazole
luliconazole