Abstract
Designing bacterial vectors for cancer therapy represents a major challenge. Recent studies have explored novel strategies to balance benefit and safety. A study by Mercado-Lubo et al. has developed a next-generation concept combining bacterial properties with nanoparticles, demonstrating efficacy in combination with chemotherapeutics.
Keywords:
Salmonella Typhimurium; Salmonella-mediated tumor therapy; SipA; nanoparticles.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Bacterial Proteins / pharmacology
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Biological Therapy / methods
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Biomimetics / methods*
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Drug Delivery Systems / methods*
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Drug Therapy
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Microfilament Proteins / pharmacology
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Nanomedicine / methods*
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Nanoparticles / chemistry
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Nanoparticles / therapeutic use
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Neoplasms / drug therapy
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Organisms, Genetically Modified
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Salmonella typhimurium / cytology*
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Salmonella typhimurium / genetics
Substances
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Bacterial Proteins
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Microfilament Proteins
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SipA protein, Salmonella