Somatostatin Receptor Type 2 (SSTR2) Internalization and Intracellular Trafficking in Pituitary GH-Secreting Adenomas: Role of Scaffold Proteins and Implications for Pharmacological Resistance

Horm Metab Res. 2017 Apr;49(4):259-268. doi: 10.1055/s-0042-116025. Epub 2016 Sep 15.

Authors

D Treppiedi¹, E Peverelli¹, E Giardino¹, E Ferrante¹, D Calebiro², A Spada¹, G Mantovani¹

Affiliations

¹ Endocrine Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
² Institute of Pharmacology and Toxicology, University of Würzburg, and Rudolf Virchow Center, Bio-Imaging Center, Würzburg, Germany.

PMID: 27632151
DOI: 10.1055/s-0042-116025

No abstract available

Publication types

Review

MeSH terms

Drug Resistance, Neoplasm*
Endocytosis*
Growth Hormone / metabolism*
Humans
Intracellular Space / metabolism*
Pituitary Neoplasms / metabolism*
Protein Transport
Receptors, Somatostatin / metabolism*

Substances

Receptors, Somatostatin
Growth Hormone
somatostatin receptor 2