Memory-effect based deconvolution microscopy for super-resolution imaging through scattering media

Sci Rep. 2016 Sep 16:6:33558. doi: 10.1038/srep33558.

Abstract

High-resolution imaging through turbid media is a fundamental challenge of optical sciences that has attracted a lot of attention in recent years for its wide range of potential applications. Here, we demonstrate that the resolution of imaging systems looking behind a highly scattering medium can be improved below the diffraction-limit. To achieve this, we demonstrate a novel microscopy technique enabled by the optical memory effect that uses a deconvolution image processing and thus it does not require iterative focusing, scanning or phase retrieval procedures. We show that this newly established ability of direct imaging through turbid media provides fundamental and practical advantages such as three-dimensional refocusing and unambiguous object reconstruction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Image Processing, Computer-Assisted*
  • Microscopy*
  • Nephelometry and Turbidimetry
  • Optical Imaging
  • Scattering, Radiation*