CD8(+) T Cells and cART: A Dynamic Duo?

Gaurav D Gaiha; Bruce D Walker

doi:10.1016/j.immuni.2016.09.003

CD8(+) T Cells and cART: A Dynamic Duo?

Immunity. 2016 Sep 20;45(3):466-468. doi: 10.1016/j.immuni.2016.09.003.

Authors

Gaurav D Gaiha¹, Bruce D Walker²

Affiliations

¹ Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
² Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 02815, USA. Electronic address: bwalker@mgh.harvard.edu.

PMID: 27653598
DOI: 10.1016/j.immuni.2016.09.003

Abstract

A new macaque study by Cartwright et al. (2016) suggests that CD8(+) T cells could play a previously unrecognized role in the suppression of HIV-1 during ongoing antiretroviral therapy.

Publication types

Review
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Anti-HIV Agents / immunology
Anti-HIV Agents / pharmacology
Anti-HIV Agents / therapeutic use
Antiretroviral Therapy, Highly Active / methods
CD8-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / virology
HIV Infections / drug therapy
HIV Infections / immunology
HIV-1 / drug effects
HIV-1 / immunology
Humans

Substances

Anti-HIV Agents

Grants and funding

HHMI/Howard Hughes Medical Institute/United States