Abstract
Autophagic degradation of ribosomes is promoted by nutrient starvation and inactivation of target of rapamycin complex 1 (TORC1). Here we show that selective autophagic degradation of ribosomes (called ribophagy) after TORC1 inactivation requires the specific autophagy receptor Atg11. Rim15 protein kinase upregulated ribophagy, while it downregulated non-selective degradation of ribosomes.
Keywords:
Rim15; Saccharomyces cerevisiae; ribophagy; target of rapamycin complex 1 (TORC1).
MeSH terms
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Autophagy*
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Autophagy-Related Proteins / metabolism
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Protein Kinases / metabolism*
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Ribosomes / metabolism*
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Saccharomyces cerevisiae / cytology*
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Saccharomyces cerevisiae / enzymology*
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins / metabolism*
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Vesicular Transport Proteins / metabolism
Substances
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Atg11 protein, S cerevisiae
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Autophagy-Related Proteins
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Saccharomyces cerevisiae Proteins
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Vesicular Transport Proteins
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Protein Kinases
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Rim15 protein, S cerevisiae
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SCH9 protein kinase