Clinical Trials of Aspirin Treatment After Desensitization in Aspirin-Exacerbated Respiratory Disease

Abstract

The clinical efficacy of aspirin treatment after desensitization in patients with respiratory disease exacerbated by nonsteroidal anti-inflammatory drugs has been documented in observational studies and in double-blind placebo-controlled trials. There is no general agreement with regard to the optimal maintenance dose or duration of treatment with acetylsalicylic acid after desensitization, thus further studies are necessary to offer clear guidelines to clinicians. This article summarizes data from noncontrolled, active-control, and placebo-controlled trials assessing clinical effectiveness and reporting on safety of treatment with acetylsalicylic acid in desensitized patients with respiratory disease exacerbated by nonsteroidal anti-inflammatory drugs.

Keywords: Aspirin desensitization; Aspirin hypersensitivity; Asthma; Chronic rhinosinusitis; NSAIDs-exacerbated respiratory disease; Nonsteroidal anti-inflammatory drugs.