A visible-light photocatalytic N-radical cascade of hydrazones for the synthesis of dihydropyrazole-fused benzosultams

Quan-Qing Zhao; Xiao-Qiang Hu; Meng-Nan Yang; Jia-Rong Chen; Wen-Jing Xiao

doi:10.1039/c6cc05897c

A visible-light photocatalytic N-radical cascade of hydrazones for the synthesis of dihydropyrazole-fused benzosultams

Chem Commun (Camb). 2016 Oct 20;52(86):12749-12752. doi: 10.1039/c6cc05897c.

Authors

Quan-Qing Zhao¹, Xiao-Qiang Hu¹, Meng-Nan Yang¹, Jia-Rong Chen¹, Wen-Jing Xiao²

Affiliations

¹ CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China. chenjiarong@mail.ccnu.edu.cn wxiao@mail.ccnu.edu.cn.
² CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China. chenjiarong@mail.ccnu.edu.cn wxiao@mail.ccnu.edu.cn and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.

PMID: 27722541
DOI: 10.1039/c6cc05897c

Abstract

An efficient visible light photocatalytic and external oxidant-free N-radical 5-exo cyclization/addition/aromatization cascade of β,γ-unsaturated hydrazones is described, which provides a practical route to various biologically interesting dihydropyrazole-fused benzosultams in satisfactory yields.