A Metabolic Roadblock in Inflammatory Macrophages

Cell Rep. 2016 Oct 11;17(3):625-626. doi: 10.1016/j.celrep.2016.09.085.

Abstract

In this issue of Cell Reports, Van den Bossche et al. (2016) reveal that, once the M1 macrophage forms, the accompanying metabolic alterations in the mitochondria are irreversible, preventing differentiation into the more homeostatic M2 macrophage.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Polarity / drug effects
  • Humans
  • Inflammation / pathology*
  • Interleukin-4 / pharmacology
  • Macrophages / drug effects
  • Macrophages / metabolism*
  • Macrophages / pathology*
  • Mice

Substances

  • Interleukin-4