Repeat surgery for recurrent low-grade gliomas should be standard of care

Clin Neurol Neurosurg. 2016 Dec:151:18-23. doi: 10.1016/j.clineuro.2016.09.013. Epub 2016 Sep 30.

Abstract

The importance of surgery and maximal extent of resection (EOR) is well established in primary low-grade glioma (LGG) management. However, the role of surgery in the management of recurrent LGG is less clear. A recent review on the management of recurrent LGG concluded there was insufficient evidence to recommend surgery. Here, we summarize the recent advances regarding the role of surgery, radiotherapy (RT) and chemotherapy in the management of recurrent LGG. There is increasing evidence to support maximal EOR for treating recurrent LGG, as it may improve progression free survival (PFS) after recurrence and overall survival (OS). Based on the studies presented in this review, we suggest that repeat surgery with maximal EOR should be standard of care for recurrent LGG treatment.

Keywords: Chemotherapy; Extent of resection; Low grade glioma; Radiotherapy; Recurrent low-grade glioma.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / radiotherapy
  • Brain Neoplasms / surgery*
  • Glioma / drug therapy
  • Glioma / radiotherapy
  • Glioma / surgery*
  • Humans
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / radiotherapy
  • Neoplasm Recurrence, Local / surgery*
  • Neurosurgical Procedures / standards*
  • Reoperation / standards*
  • Standard of Care / standards*