Cell-Free miRNA-141 and miRNA-205 as Prostate Cancer Biomarkers

Adv Exp Med Biol. 2016:924:9-12. doi: 10.1007/978-3-319-42044-8_2.

Abstract

Expression levels of five miRNAs (miR-19b, miR-21, miR-126, miR-141, miR-205) were measured in the plasma of healthy donors and prostate cancer patients. It was shown that miR-141 expression level efficiently discriminates early stage prostate cancer patients and correlates with the Gleason score.

Keywords: Biomarkers; Prostate cancer; miRNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / blood
  • Biomarkers, Tumor / genetics*
  • Cohort Studies
  • Diagnosis, Differential
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Logistic Models
  • Male
  • MicroRNAs / blood
  • MicroRNAs / genetics*
  • Neoplasm Grading
  • Neoplasm Staging
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / diagnosis
  • Prostatic Neoplasms / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sensitivity and Specificity
  • Up-Regulation

Substances

  • Biomarkers, Tumor
  • MIRN141 microRNA, human
  • MIRN205 microRNA, human
  • MicroRNAs