The genome of serotype VI Streptococcus agalactiae serotype VI and comparative analysis

Gene. 2017 Jan 15:597:59-65. doi: 10.1016/j.gene.2016.10.030. Epub 2016 Oct 20.

Abstract

Streptococcus agalactiae (GBS) causes serious infections in humans and other species. A total of 25 complete GBS genomes, including the first sequenced serotype VI genome (GBS-M002), were compared in this study. The power law model suggested that the pan-genome of GBS is open, with approximately 1300 genes in the core genome of GBS, accounting for approximately 60% of the average genome content. GBS-M002 has 73 specific genes and is one of the five strains containing >60 specific genes. Based on COG (Cluster of Orthologous Groups of proteins) functional classification, 24% of the genes related to defense mechanisms are specific among the strains. A phylogenetic tree shows that GBS-M002 is closely related to certain strains of serotypes III and V from humans and to isolates of unknown serotype from dog and bovine hosts, suggesting the universal infection potential of GBS from humans to other mammal and fish hosts.

Keywords: Genomic analysis; Pan-genome; Streptococcus agalactiae.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Cattle
  • Dogs
  • Genome, Bacterial*
  • Genomic Islands / genetics
  • Humans
  • Phylogeny
  • Sequence Analysis, DNA
  • Streptococcus agalactiae / genetics*
  • Streptococcus agalactiae / isolation & purification
  • Streptococcus agalactiae / pathogenicity*

Substances

  • Bacterial Proteins