WASP and WAVE Team Up at the Leading Edge

Dev Cell. 2016 Oct 24;39(2):135-136. doi: 10.1016/j.devcel.2016.10.008.

Abstract

Arp2/3-dependent branched actin networks drive membrane protrusions, with WAVE being recognized as the critical Arp2/3 activator in this process. In this issue of Developmental Cell, Zhu et al. (2016) demonstrate that WASP, an Arp2/3 activator mostly involved in endocytosis, collaborates with WAVE to promote migration of neuroblasts in Caenorhabditis elegans.

Publication types

  • Comment

MeSH terms

  • Actin-Related Protein 2-3 Complex*
  • Actins
  • Animals
  • Caenorhabditis elegans
  • Endocytosis
  • Wiskott-Aldrich Syndrome Protein*

Substances

  • Actin-Related Protein 2-3 Complex
  • Actins
  • Wiskott-Aldrich Syndrome Protein