Abstract
The advent of mitochondrial replacement techniques poses many scientific, regulatory, and ethical questions. Previous studies suggest good safety and efficacy profiles of these techniques, but challenges remain for clinical implementation and international consensus is needed on the regulation of these approaches.
MeSH terms
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Animals
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DNA, Mitochondrial / genetics*
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Female
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Fertilization in Vitro / ethics
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Genes, Mitochondrial*
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Haplorhini
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Humans
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Inheritance Patterns
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Male
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Mice
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Mitochondria / genetics
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Mitochondria / transplantation*
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Mitochondrial Diseases / genetics
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Mitochondrial Diseases / pathology
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Mitochondrial Diseases / prevention & control*
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Mitochondrial Replacement Therapy / ethics
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Mitochondrial Replacement Therapy / methods*
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Oocytes / metabolism
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Oocytes / pathology
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Spermatozoa / cytology
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Spermatozoa / metabolism
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Spindle Apparatus / genetics
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Spindle Apparatus / transplantation