Soft Tissue Regeneration Incorporating 3-Dimensional Biomimetic Scaffolds

Gaurav Shah; Bernard J Costello

doi:10.1016/j.coms.2016.08.003

Soft Tissue Regeneration Incorporating 3-Dimensional Biomimetic Scaffolds

Oral Maxillofac Surg Clin North Am. 2017 Feb;29(1):9-18. doi: 10.1016/j.coms.2016.08.003.

Authors

Gaurav Shah¹, Bernard J Costello²

Affiliations

¹ Department of Oral and Maxillofacial Surgery, University of Pittsburgh School of Dental Medicine, 214 Eye and Ear Institute, 203 Lothrop Street, Pittsburgh, PA 15213, USA.
² Cranofacial Cleft Surgery, Department of Oral and Maxillofacial Surgery, University of Pittsburgh School of Dental Medicine, 214 Eye and Ear Institute, 203 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address: bjc1@pitt.edu.

PMID: 27890231
DOI: 10.1016/j.coms.2016.08.003

Abstract

Soft tissue replacement and repair is crucial to the ever-developing field of reconstructive surgery as trauma, pathology, and congenital deficits cannot be adequately restored if soft tissue regeneration is deficient. Predominant approaches were sometimes limited to harvesting autografts, but through regenerative medicine and tissue engineering, the hope of fabricating custom constructs is now a feasible and fast-approaching reality. The breadth of this field includes tissues ranging from skin, mucosa, muscle, and fat and hopes to not only provide construct to replace a tissue but also to replace its function.

Keywords: 3-dimensional printing; Computer-aided design/computer-aided manufacturing; Scaffolds; Soft tissue engineering.

Publication types

Review

MeSH terms

Animals
Bioprosthesis
Computer-Aided Design
Humans
Oral Surgical Procedures / methods*
Plastic Surgery Procedures / methods*
Printing, Three-Dimensional*
Regenerative Medicine / methods*
Tissue Scaffolds*