Abstract
A number of N-oxides of 4'-(benzotriazol-2-yl)-phenylalkanoic and -phenoxyalkanoic acids bearing various substituents on position 6 of benzotriazole together with 4'-(benzotriazol-2-yl) phenylacetic acid were prepared and subjected to a wide pharmacological screening. Several compounds exhibited significant antiinflammatory and diuretic activities, while one was endowed with antihypertensive activity.
Publication types
-
English Abstract
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
-
Antihypertensive Agents / chemical synthesis*
-
Carboxylic Acids / chemical synthesis*
-
Carboxylic Acids / pharmacology
-
Chemical Phenomena
-
Chemistry
-
Diuretics / chemical synthesis*
-
Hemodynamics / drug effects
-
Male
-
Mice
-
Motor Activity / drug effects
-
Postural Balance / drug effects
-
Rats
-
Triazoles / chemical synthesis*
-
Triazoles / pharmacology
-
Urodynamics / drug effects
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antihypertensive Agents
-
Carboxylic Acids
-
Diuretics
-
Triazoles