Interleukin 1 and tumor necrosis factor: studies on the induction by lipopolysaccharide partial structures

H D Flad; H Loppnow; W Feist; M H Wang; H Brade; S Kusumoto; E T Rietschel; A J Ulmer

Interleukin 1 and tumor necrosis factor: studies on the induction by lipopolysaccharide partial structures

Lymphokine Res. 1989 Fall;8(3):235-8.

Authors

H D Flad¹, H Loppnow, W Feist, M H Wang, H Brade, S Kusumoto, E T Rietschel, A J Ulmer

Affiliation

¹ Forschungsinstitut Borstel, FRG.

PMID: 2789317

Abstract

Minimal concentration ranges of lipopolysaccharides, natural and synthetic lipid As, and partial structures were established for the induction of release of IL-1 and TNF from human MNC. LPS was more potent than lipid A. Partial structures of lipid A lacking nonhydroxylated fatty acids were inactive, but in combination with LPS or lipid A exhibited time-dependent synergistic or antagonistic effects.

MeSH terms

Glycolipids / pharmacology
Humans
In Vitro Techniques
Interleukin-1 / biosynthesis*
Leukocytes, Mononuclear / drug effects
Leukocytes, Mononuclear / immunology
Leukocytes, Mononuclear / metabolism
Lipid A / pharmacology
Lipopolysaccharides / pharmacology*
Tumor Necrosis Factor-alpha / biosynthesis*

Substances

Glycolipids
Interleukin-1
Lipid A
Lipopolysaccharides
Tumor Necrosis Factor-alpha
lipid X