1 Campus of Hematology Franco e Piera Cutino, AOOR Villa Sofia-V. Cervello, Palermo, Italy.
2 Dipartimento Attività Sanitarie e Osservatorio Epidemiologico Assessorato Salute Regione Sicilia, Palermo, Italy.
3 The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.