Novel antitumor antibiotic phospholine. 1. Production, isolation and characterization

J Antibiot (Tokyo). 1989 Sep;42(9):1331-8. doi: 10.7164/antibiotics.42.1331.

Abstract

Phospholine was isolated as an antitumor antibiotic from the fermentation broth of Streptomyces hygroscopicus. Phospholine is an amphoteric compound which has an amino group and a phosphoric acid ester as functional groups. Phospholine shows strong activities against L1210, P388 and EL-4.

MeSH terms

  • Antibiotics, Antineoplastic / analysis
  • Antibiotics, Antineoplastic / isolation & purification*
  • Chemical Phenomena
  • Chemistry
  • Fermentation
  • Lactones / isolation & purification
  • Lactones / therapeutic use
  • Leukemia, Experimental / drug therapy
  • Magnetic Resonance Spectroscopy
  • Organophosphorus Compounds / isolation & purification
  • Organophosphorus Compounds / therapeutic use
  • Streptomyces

Substances

  • Antibiotics, Antineoplastic
  • Lactones
  • Organophosphorus Compounds
  • phospholine