Fidgetin regulates cultured astrocyte migration by severing tyrosinated microtubules at the leading edge

Mol Biol Cell. 2017 Feb 15;28(4):545-553. doi: 10.1091/mbc.E16-09-0628. Epub 2016 Dec 14.

Abstract

Microtubule (MT) organization is essential for many cellular events, including mitosis, migration, and cell polarity. Fidgetin (Fign), an ATP-dependent, MT-severing protein, contributes to the regulation of MT configuration by cutting and trimming MT polymers. Functions of Fign have been indicated in neurite outgrowth, mitosis, meiosis, and cellular migration. Here we focus on migration of astrocytes. We find that Fign plays an essential role in cultured astrocyte migration by preferentially targeting MTs (or regions of MTs) that are rich in tyrosinated tubulin, a marker for especially dynamic MTs or especially dynamic regions of MTs. Inhibition of cellular migration induced by Fign knockdown can be rescued with concomitant knockdown of kinesin-12, a motor protein best known for its role in mitosis. We propose a novel working model for MT reconfiguration underlying cellular migration elicited by the functional cooperation of two distinct MT-related proteins.

MeSH terms

  • ATPases Associated with Diverse Cellular Activities
  • Adenosine Triphosphatases / metabolism*
  • Adenosine Triphosphatases / physiology
  • Animals
  • Astrocytes / metabolism
  • Cell Movement / physiology*
  • Cells, Cultured
  • Kinesins / metabolism
  • Microtubule-Associated Proteins
  • Microtubules / metabolism*
  • Neurogenesis
  • Neurons / metabolism
  • Nuclear Proteins / metabolism*
  • Nuclear Proteins / physiology
  • Rats
  • Tubulin / metabolism
  • Tyrosine

Substances

  • Microtubule-Associated Proteins
  • Nuclear Proteins
  • Tubulin
  • Tyrosine
  • Adenosine Triphosphatases
  • ATPases Associated with Diverse Cellular Activities
  • Fign protein, mouse
  • Kinesins