Shaping Early Networks to Rule Mature Circuits: Little MiRs Go a Long Way

Andre Marques-Smith; Emilia Favuzzi; Beatriz Rico

doi:10.1016/j.neuron.2016.12.014

Shaping Early Networks to Rule Mature Circuits: Little MiRs Go a Long Way

Neuron. 2016 Dec 21;92(6):1154-1157. doi: 10.1016/j.neuron.2016.12.014.

Authors

Andre Marques-Smith¹, Emilia Favuzzi¹, Beatriz Rico²

Affiliations

¹ Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
² Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK. Electronic address: beatriz.rico@kcl.ac.uk.

PMID: 28009269
DOI: 10.1016/j.neuron.2016.12.014

Abstract

Normative cortical processing depends on precise interactions between excitatory and inhibitory neurons. In this issue of Neuron, Lippi et al. (2016) identify miR-101 as a master regulator coordinating molecular programs during development that ultimately impact the activity of mature networks.

Keywords: E/I balance; development; microRNAs; neural circuits.

MeSH terms

Cerebral Cortex / physiology*
Humans
MicroRNAs
Neurons*

Substances

MIRN101 microRNA, human
MicroRNAs