dAPE: a web server to detect homorepeats and follow their evolution

Bioinformatics. 2017 Apr 15;33(8):1221-1223. doi: 10.1093/bioinformatics/btw790.

Abstract

Summary: Homorepeats are low complexity regions consisting of repetitions of a single amino acid residue. There is no current consensus on the minimum number of residues needed to define a functional homorepeat, nor even if mismatches are allowed. Here we present dAPE, a web server that helps following the evolution of homorepeats based on orthology information, using a sensitive but tunable cutoff to help in the identification of emerging homorepeats.

Availability and implementation: dAPE can be accessed from http://cbdm-01.zdv.uni-mainz.de/∼munoz/polyx .

Contact: munoz@uni-mainz.de.

Supplementary information: Supplementary data are available at Bioinformatics online.

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Humans
  • Internet
  • Repetitive Sequences, Amino Acid*
  • Sequence Alignment
  • Software*