Relevant Discordance Between 68Ga-DOTATATE and 68Ga-DOTANOC in SDHB-Related Metastatic Paraganglioma: Is Affinity to Somatostatin Receptor 2 the Key?

Clin Nucl Med. 2017 Mar;42(3):211-213. doi: 10.1097/RLU.0000000000001504.

Abstract

Pheochromocytomas/paragangliomas are somatostatin receptor 2-overexpressing tumors. Ga-DOTA-peptide imaging has recently shown excellent results in the detection of metastatic lesions in these tumors. However, currently used Ga-DOTA peptides show different somatostatin receptor affinities. Here, we report the remarkable differences in a patient who was imaged with Ga-DOTANOC and Ga-DOTATATE PET/CT within a 7-month period. The patient presented with a nearly negative Ga-DOTANOC PET/CT scan, whereas on Ga-DOTATATE PET/CT, multiple highly positive lesions were identified.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Neoplasms / diagnostic imaging*
  • Abdominal Neoplasms / genetics
  • Abdominal Neoplasms / pathology
  • Child
  • Female
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / secondary*
  • Neoplasm Metastasis
  • Organometallic Compounds*
  • Paraganglioma / diagnostic imaging*
  • Paraganglioma / genetics
  • Paraganglioma / pathology
  • Positron Emission Tomography Computed Tomography
  • Protein Binding
  • Radiopharmaceuticals*
  • Receptors, Somatostatin / metabolism*
  • Succinate Dehydrogenase / genetics

Substances

  • 68Ga-DOTANOC
  • Organometallic Compounds
  • Radiopharmaceuticals
  • Receptors, Somatostatin
  • gallium Ga 68 dotatate
  • somatostatin receptor 2
  • SDHB protein, human
  • Succinate Dehydrogenase