Abstract
Inflammation is a common symptom of inflammatory bowel disease (IBD). Actually, many experimental models of colitis exist and try to mimic the human situation in order to understand the pathogenesis of Crohn's disease and ulcerative colitis. These experimental models of inflammation can be characterized by specific parameters, which illustrate the proceeding inflammatory process. By use of these models potentially new reagents for improved therapeutic approaches can be analyzed. Here, we describe the TNBS-mediated colitis model and specify different parameters for the detailed characterization of the inflammatory process in experimental colitis models.
Keywords:
Colitis; Inflammatory bowel disease; Lamina propria; Mucosal immunology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, CD / genetics
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Antigens, CD / immunology
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Antigens, Differentiation / genetics
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Antigens, Differentiation / immunology
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Biomarkers / metabolism
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Body Weight
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Colitis / chemically induced
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Colitis / immunology*
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Colitis / pathology
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Colonoscopy / instrumentation
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Colonoscopy / methods*
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Cytokines / genetics
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Cytokines / immunology*
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Disease Models, Animal
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Gene Expression
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Humans
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Immunity, Mucosal
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Immunohistochemistry / methods*
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Mice
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Mucous Membrane / immunology*
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Mucous Membrane / pathology
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Peroxidase / genetics
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Peroxidase / immunology
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Severity of Illness Index
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Trinitrobenzenesulfonic Acid
Substances
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Antigens, CD
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Antigens, Differentiation
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Biomarkers
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Cytokines
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monocyte-macrophage differentiation antigen
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Trinitrobenzenesulfonic Acid
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Peroxidase