Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model

Abstract

In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch.

Keywords: chitosan; congenital heart defects; heart patch; polycaprolactone; right ventricular outflow tract.