Abstract
We studied the effects of nanodispersed ceria on wound healing in vitro and in vivo. It was found that cerium dioxide stimulated wound healing, which manifested in shrinkage of burn wound area (by 1.5 times) and intensification (by 2.4 times) marginal epithelialization.
Keywords:
burn simulation; cell viability; cut wound simulation; nanodispersed cerium dioxide; wound regeneration.
MeSH terms
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Administration, Cutaneous
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Animals
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Burns, Chemical / drug therapy*
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Burns, Chemical / pathology
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Cell Culture Techniques
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Cell Survival / drug effects
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Cerium / pharmacology*
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Embryo, Mammalian
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Epithelial Cells / cytology
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Epithelial Cells / drug effects
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Mesenchymal Stem Cells / cytology
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Mesenchymal Stem Cells / drug effects
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Mice
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Nanostructures / administration & dosage*
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Rats
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Rats, Wistar
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Re-Epithelialization / drug effects*
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Re-Epithelialization / physiology
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Skin / drug effects*
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Skin / injuries
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Skin / pathology