Toward the Atomic Structure of PrPSc

Jose A Rodriguez; Lin Jiang; David S Eisenberg

doi:10.1101/cshperspect.a031336

Toward the Atomic Structure of PrP^Sc

Cold Spring Harb Perspect Biol. 2017 Sep 1;9(9):a031336. doi: 10.1101/cshperspect.a031336.

Authors

Jose A Rodriguez¹, Lin Jiang², David S Eisenberg³

Affiliations

¹ Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, California 90095.
² Department of Neurology, Molecular Biology Institute (MBI), and Brain Research Institute (BRI), David Geffen School of Medicine, University of California, Los Angeles, California 90095.
³ Department of Biological Chemistry, UCLA-DOE Institute for Genomics and Proteomics, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.

Abstract

In this review, we detail our current knowledge of PrP^Sc structure on the basis of structural and computational studies. We discuss the progress toward an atomic resolution description of PrP^Sc and results from the broader field of amyloid studies that may further inform our knowledge of this structure. Moreover, we summarize work that investigates the role of PrP^Sc structure in its toxicity, transmissibility, and species specificity. We look forward to an atomic model of PrP^Sc, which is expected to bring diagnostics and/or therapeutics to the field of prion disease.

Publication types

Review

MeSH terms

Amyloidogenic Proteins / chemistry
Fungal Proteins / chemistry
Models, Molecular
Nuclear Magnetic Resonance, Biomolecular
PrPSc Proteins / chemistry*
Protein Structure, Tertiary
Sequence Analysis, Protein
Species Specificity

Substances

Amyloidogenic Proteins
Fungal Proteins
PrPSc Proteins