A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26447. Epub 2017 Jan 18.

Abstract

The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.

Keywords: HPA; Turner syndrome; neonatal thrombocytopenia; oocyte donor; surrogate pregnancy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, Human Platelet / genetics*
  • Female
  • Genotype
  • Humans
  • Pregnancy
  • Real-Time Polymerase Chain Reaction
  • Thrombocytopenia, Neonatal Alloimmune / genetics*
  • Tissue Donors*

Substances

  • Antigens, Human Platelet