Is It Time to Include CT "Reverse Halo Sign" and qPCR Targeting Mucorales in Serum to EORTC-MSG Criteria for the Diagnosis of Pulmonary Mucormycosis in Leukemia Patients?

Denis Caillot; Stéphane Valot; Ingrid Lafon; Louise Basmaciyan; Marie Lorraine Chretien; Marc Sautour; Laurence Million; Caroline Legouge; Alexandre Payssot; Frédéric Dalle

doi:10.1093/ofid/ofw190

Is It Time to Include CT "Reverse Halo Sign" and qPCR Targeting Mucorales in Serum to EORTC-MSG Criteria for the Diagnosis of Pulmonary Mucormycosis in Leukemia Patients?

Open Forum Infect Dis. 2016 Nov 8;3(4):ofw190. doi: 10.1093/ofid/ofw190. eCollection 2016 Oct.

Affiliations

¹ Department of Clinical Haematology, University Hospital, Dijon; Inserm Unit 866, LabEx Team, Dijon School of Medicine.
² Mycology and Parasitology Department , University Hospital , Dijon.
³ Department of Clinical Haematology , University Hospital , Dijon.
⁴ Mycology and Parasitology Department, University Hospital, Dijon; Bourgogne Franche-Comté University, Agrosup Dijon, UMR PAM, Team Vin, Aliment, Microbiologie, Stress.
⁵ Chrono-Environnement UMR, 6249 CNRS, Bourgogne Franche-Comté University, Besançon; Parasitology-Mycology Department, University Hospital, Besançon, France.

Abstract

In 23 leukemia patients with proven (n = 17) or possible (n = 6) pulmonary mucormycosis (PM), the presence of reversed halo sign on computed tomography was strongly associated with the positivity of quantitative polymerase chain reaction assays targeting Mucorales in the serum, confirming the value of these two tools for the diagnosis of PM in this setting.

Keywords: early diagnosis; leukemia; pulmonary mucormycosis; quantitative polymerase chain reaction; reversed halo sign.