A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo

Cell Res. 2017 Mar;27(3):440-443. doi: 10.1038/cr.2017.16. Epub 2017 Jan 24.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • CRISPR-Associated Protein 9 / metabolism*
  • CRISPR-Cas Systems / genetics*
  • DNA, Viral / metabolism*
  • Gene Targeting
  • HEK293 Cells
  • Hepatitis B virus / genetics*
  • Humans
  • Lipids / chemistry
  • Liver / metabolism
  • Mice
  • Mice, Inbred C57BL
  • NIH 3T3 Cells
  • Nanoparticles / chemistry
  • Proprotein Convertase 9 / metabolism*

Substances

  • DNA, Viral
  • Lipids
  • CRISPR-Associated Protein 9
  • Proprotein Convertase 9