Abstract
The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
MeSH terms
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Animals
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CRF Receptor, Type 1
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Corticotropin-Releasing Hormone / pharmacology
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Corticotropin-Releasing Hormone / physiology
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Cortisone / blood
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Hypothalamo-Hypophyseal System / physiology*
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Locomotion / physiology
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Male
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Maze Learning / physiology
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Mice
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Mice, Knockout
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Mice, Transgenic
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Paraventricular Hypothalamic Nucleus / physiology*
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Pituitary-Adrenal System / physiology*
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Receptors, Corticotropin-Releasing Hormone / genetics
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Receptors, Corticotropin-Releasing Hormone / physiology*
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Stress, Physiological / physiology*
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Stress, Psychological / physiopathology*
Substances
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Receptors, Corticotropin-Releasing Hormone
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CRF Receptor, Type 1
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Corticotropin-Releasing Hormone
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Cortisone