Abstract
Four studies in this issue report new mechanisms underlying the function of the chromatin remodeling SWI/SNF complex in controlling gene expression and suppressing tumor development, providing valuable insights into the treatment of cancers harboring mutations in genes encoding SWI/SNF complex subunits.
MeSH terms
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Animals
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Chromatin / chemistry*
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Chromatin / metabolism
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Chromatin Assembly and Disassembly
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Chromosomal Proteins, Non-Histone / genetics*
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Chromosomal Proteins, Non-Histone / metabolism
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Drosophila Proteins / genetics*
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Drosophila Proteins / metabolism
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Drosophila melanogaster / genetics
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Drosophila melanogaster / metabolism
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Gene Expression Regulation, Neoplastic*
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Histone-Lysine N-Methyltransferase / genetics*
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Histone-Lysine N-Methyltransferase / metabolism
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Humans
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Mice
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Microtubule-Associated Proteins
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Neoplasms / genetics*
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Neoplasms / metabolism
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Neoplasms / pathology
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Polycomb-Group Proteins / genetics*
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Polycomb-Group Proteins / metabolism
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SMARCB1 Protein / genetics
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SMARCB1 Protein / metabolism
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Transcription Factors / genetics*
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Transcription Factors / metabolism
Substances
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Arid1a protein, mouse
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Arid1b protein, mouse
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Chromatin
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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Drosophila Proteins
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Feo protein, Drosophila
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Microtubule-Associated Proteins
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Nuclear Proteins
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Polycomb-Group Proteins
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SMARCB1 Protein
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SMARCB1 protein, human
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SWI-SNF-B chromatin-remodeling complex
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Transcription Factors
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Histone-Lysine N-Methyltransferase
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PRC2 protein, Drosophila