Inhibitory antibodies against factor VIII C1 domain

Blood. 2016 Oct 20;128(16):2001-2002. doi: 10.1182/blood-2016-08-727818.

Abstract

In this issue of Blood, Batsuli et al demonstrate that pathogenic antibodies against the factor VIII (fVIII) C1 domain are more common than previously appreciated and that they can cause bleeding through a novel mechanism.

Publication types

  • Comment

MeSH terms

  • Antibodies, Monoclonal
  • Factor VIII / immunology*
  • Hemophilia A / immunology
  • Humans
  • Protein Domains*

Substances

  • Antibodies, Monoclonal
  • Factor VIII