The topological phase diagram of cimetidine: A case of overall monotropy

R Céolin; I B Rietveld

doi:10.1016/j.pharma.2016.11.002

The topological phase diagram of cimetidine: A case of overall monotropy

Ann Pharm Fr. 2017 Mar;75(2):89-94. doi: 10.1016/j.pharma.2016.11.002. Epub 2017 Feb 1.

Authors

R Céolin¹, I B Rietveld²

Affiliations

¹ Letiam, EA7357, IUT Orsay, université Paris-Sud, rue Noetzlin, 91405 Orsay cedex, France.
² Caracterisation des matériaux moléculaires à activité thérapeutique (CAMMAT), faculté de pharmacie, université Paris-Descartes, 4, avenue de l'observatoire, 75006 Paris, France. Electronic address: ivo.rietveld@parisdescartes.fr.

PMID: 28160941
DOI: 10.1016/j.pharma.2016.11.002

Abstract

Cimetidine is a histamine H₂-receptor antagonist used against peptic ulcers. It is known to exhibit crystalline polymorphism. Forms A and D melt within 0.35 degrees from each other and the enthalpies of fusion are similar as well. The present paper demonstrates how to construct a pressure-temperature phase diagram with only calorimetric and volumetric data available. The phase diagram provides the stability domains and the phase equilibria for the phases A, D, the liquid and the vapor. Cimetidine is overall monotropic with form D the only stable solid phase.

Keywords: Cimetidine; Cimétidine; Crystalline polymorphism; Diagramme P-T topologique; Polymorphisme cristallin; Stabilité thermodynamique; Thermodynamic stability; Topological P-T diagram.

MeSH terms

Calorimetry
Cimetidine / chemistry*
Crystallization
Drug Stability
Pressure
Temperature
Thermodynamics

Substances

Cimetidine