Valproic acid-induced hyperammonemic encephalopathy in a full-term neonate: a brief review and case report

Pavla Pokorná; Karolina Hronová; Martin Šíma; Ondřej Slanař; Petr Klement; John N van den Anker; Dick Tibboel

doi:10.1007/s00228-017-2208-4

Valproic acid-induced hyperammonemic encephalopathy in a full-term neonate: a brief review and case report

Eur J Clin Pharmacol. 2017 May;73(5):647-649. doi: 10.1007/s00228-017-2208-4. Epub 2017 Feb 6.

Authors

Pavla Pokorná^{1

2

3}, Karolina Hronová⁴, Martin Šíma⁴, Ondřej Slanař⁴, Petr Klement⁵, John N van den Anker^{6

7

8

9

10}, Dick Tibboel^{5

11}

Affiliations

¹ Department of Pediatrics, General Faculty Hospital Prague, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 128 08, Prague, Czech Republic. pokornakarlov@seznam.cz.
² Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Albertov 4, 128 00, Prague 2, Czech Republic. pokornakarlov@seznam.cz.
³ Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. pokornakarlov@seznam.cz.
⁴ Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Albertov 4, 128 00, Prague 2, Czech Republic.
⁵ Department of Pediatrics, General Faculty Hospital Prague, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 128 08, Prague, Czech Republic.
⁶ Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.
⁷ Department of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.
⁸ Division of Clinical Pharmacology, Children's National Health System, Washington, D.C., USA.
⁹ Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
¹⁰ Division of Paediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.
¹¹ Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

PMID: 28168312
DOI: 10.1007/s00228-017-2208-4

No abstract available

Publication types

Case Reports
Letter
Review

MeSH terms

Anticonvulsants / administration & dosage
Anticonvulsants / adverse effects*
Brain Diseases / chemically induced*
Humans
Hyperammonemia / chemically induced*
Infant, Newborn
Seizures / drug therapy
Valproic Acid / administration & dosage
Valproic Acid / adverse effects*

Substances

Anticonvulsants
Valproic Acid