Effect of alcohol and its metabolites in lung cancer: CAPUA study

Abstract

Background and objective: Alcohol and its metabolites play an important role in carcinogenesis. This effect could be modulated by polymorphisms in genes encoding enzymes involved in the metabolism of alcohol and folate. Therefore, we analyzed the effect of alcohol consumption and ADH1B Arg48His, ADH1B Arg370Cys, ADH1C Ile349Val, ALDH2 Glu540Lys, CYP2E1 RsaI, CYP2E1 DraI, CYP2E1 TaqI and MTHFR C677T polymorphisms on the risk of developing lung cancer.

Patients and methods: We included 876 lung cancer cases and 840 controls of the CAPUA hospital-based case-control study. Genotyping was performed using the Sequenom MassArray (iPLEX GOLD) technology.

Results: An alcohol consumption of 0.1-9.9g/day decreased lung cancer risk (OR_adjusted=0.71; 95% CI 0.48-1.05), although statistical significance was not achieved. A consumption≥30g/day of alcohol and≥36PY of tobacco increases lung cancer risk (OR_adjusted=26.68; 95% CI 12.69-56.10). On the other hand, a high consumption of vegetables (≥116.65g/day) and fruits (≥233.13g/day) decreases lung cancer risk with an alcohol consumption of 0.1-9.9g/day (OR_adjusted=0.52; 95% CI 0.30-0.89; OR_adjusted=0.58; 95% CI 0.33-1.03, respectively). An alcohol consumption of 10-29.9g/day in ADH1B 48His allele-carriers increases lung cancer risk (OR_adjusted=3.32; 95% CI 1.03-10.70).

Conclusions: Alcohol and polymorphisms in genes involved in the metabolism of alcohol and folate are related to the onset of lung cancer.

Keywords: Acetaldehyde; Acetaldehído; Alcohol; Cáncer de pulmón; Folate; Folato; Lung cancer; Polimorfismos; Polymorphisms.