Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy

Chem Commun (Camb). 2017 Mar 16;53(23):3303-3306. doi: 10.1039/c6cc09470h.

Abstract

We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(iii) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / radiation effects
  • Cell Nucleus / metabolism*
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / pharmacology*
  • Coordination Complexes / radiation effects
  • DNA / genetics
  • DNA Damage / drug effects
  • Endocytosis / drug effects
  • Female
  • Hep G2 Cells
  • Humans
  • Iridium / chemistry*
  • Iridium / radiation effects
  • Mice, Inbred BALB C
  • Mitochondria / metabolism
  • Photochemotherapy*
  • Ultraviolet Rays

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • Iridium
  • DNA