Abstract
We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(iii) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / radiation effects
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Cell Nucleus / metabolism*
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Coordination Complexes / chemical synthesis
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Coordination Complexes / pharmacology*
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Coordination Complexes / radiation effects
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DNA / genetics
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DNA Damage / drug effects
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Endocytosis / drug effects
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Female
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Hep G2 Cells
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Humans
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Iridium / chemistry*
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Iridium / radiation effects
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Mice, Inbred BALB C
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Mitochondria / metabolism
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Photochemotherapy*
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Ultraviolet Rays
Substances
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Antineoplastic Agents
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Coordination Complexes
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Iridium
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DNA